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Cardiovascular Diseases

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Genetic testing in a patient diagnosed with hypertrophic cardiomyopathy (HCM) reveals a mutation in the MYBPC3 gene. This finding suggests a familial form of HCM. What is the recommended advice for the patient's first-degree relatives?
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Which of the following types of cardiomyopathies is most associated with a history of chemotherapy or radiation therapy?
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An

82-years-old retired solicitor presents to the ED with chest pain radiating to

his jaw. He has hypertension treated with ramipril 5 mg bid (ACE inhibitor) but

is otherwise normally fit and well. His admission ECG shows sinus rhythm with

ventricular rate of 57 bpm, LV hypertension, and widespread ST segment

depression. His peak troponin is 110 ng/l (normal <30 ng/l). He is started

on treatment for an acute coronary syndrome and listed for an inpatient

angiogram. You are asked to perform bedside echocardiogram as a systolic murmur

is heard on the post-take ward round. His aortic valve is heavy calcified,

maximal trans-aortic jet velocity is 4.3 m/s, peak trans-aortic gradient is 75

mmHg, mean trans-aortic gradient is 46 mmHg (Figure below). 

What is the next appropriate step in the

management of the above-described patient?

 

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Please name the type of aortic dissection shown below:

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An 80-year-old

woman is admitted with acute pulmonary oedema on a background of progressive

shortness of breath with exertional chest pain for 6 months. She has a history

of renal impairment with a eGFR of 40 ml/min. She is initially commenced on IV

furosemide with good effect. An echocardiogram reveals LVEF 40% with severe

aortic stenosis (AS) with an estimated valve area of 0.7 cm2. She is on sinus

rhythm, 90 bpm. What would you do next?

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Please identify the correct diagnosis based on images below a) chest x-ray (left) and b) computed tomography image (right).

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A 65-year-old man with a known ascending thoracic aortic aneurysm (5 cm) and a bicuspid aortic valve is being followed on a yearly basis by a referring physician. The most recent TTE shows an increase in the diameter of the aneurysm to 5.8 cm. The patient is referred to you for further evaluation. You want to confirm the results of the echocardiogram. You should consider ordering:
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Three main symptoms in patients with severe symptomatic aortic stenosis are presented below. Which symptom heralds the worst prognosis with median survival of two years?

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Please identify the correct diagnosis based on images below a) chest x-ray (left) and b) computed tomography image (right).

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An

82-years-old retired solicitor presents to the ED with chest pain radiating to

his jaw. He has hypertension treated with ramipril 5 mg bid (ACE inhibitor) but

is otherwise normally fit and well. His admission ECG shows sinus rhythm with

ventricular rate of 57 bpm, LV hypertension, and widespread ST segment

depression. His peak troponin is 110 ng/l (normal <30 ng/l). He is started

on treatment for an acute coronary syndrome and listed for an inpatient

angiogram. You are asked to perform bedside echocardiogram as a systolic murmur

is heard on the post-take ward round. His aortic valve is heavy calcified,

maximal trans-aortic jet velocity is 4.3 m/s, peak trans-aortic gradient is 75

mmHg, mean trans-aortic gradient is 46 mmHg (Figure below). 

What is the most likely diagnosis?

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