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BMS/GNA2042 - Human Genetics - S2 2025

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i. In an analysis, the heritability of a phenotypic trait was

calculated to be 0.8. What does this mean?

ii. In the

same analysis, the narrow sense heritability of the same phenotypic trait was

calculated to be 0.7. What does this mean?

Note: On quiz submission you should be able to access an exemplar to compare your answer to. 

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A parent carries a pathogenic allele for an autosomal dominant condition and their partner is unaffected. The impacted gene is in linkage with a molecular marker ‘Q’, which is 15 map units apart from the gene. Analysis of the family pedigree and genotyping has identified the pathogenic allele is on the same chromosome as the ‘Q4’ allele of the Q locus, while the non-pathogenic allele is on the same chromosome as the ‘Q6’ allele.

Their child has inherited the Q6 allele from the affected parent. What is the chance the child is also affected with the condition?

Enter the chance as a percentage (%) to a maximum of 1 decimal place, without units. 

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From the data in Q6 are the A and B markers more likely to be independently assorting or linked?

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