decreased breakdown of insulin

decreased number of insulin receptors

congenital defect of insulin receptors

decreased insulin concentration in blood

insufficiency of neutralization of biological substances during acute inflammation

increased sensitivity of the immune system to exogenous antigen

induction of mast cell degranulation

increased sensitivity to modified/sequestered body's own antigens

accumulation of fluid in the body cavity

fluid retention in the intravascular space

accumulation of fluid in the intercellular space

accumulation of fluid in the intracellular space

swelling

capillary -trophic insufficiency

venous hyperemia

ischemia

hematogenous

specific tissue elements

neuroectodermal

mesenchymal

generalized formation of thrombo /leukocyte aggregates on the walls of microvessels

first stage of intravascular coagulation

coagulation of blood proteins in microvessels

aggregation of erythrocytes in microvessels in combination with an increase in viscosity and blood separation

arterial hyperemia

arterial hyperemia

stasis

venous hyperemia

ischemia

comparison of the clinics   with data from epidemiological studies

analysis of biochemical parameters

assessment of clinical manifestations of the disease

drawing up the patient’s pedigree