Liver enlargement

Right ventricular hypertrophy

Enlarged spleen

Left ventricular hypertrophy

Secondary hyperaldosteronism

Autonomic hypersecretion of adrenaline and norepinephrine by the adrenal medulla

Increased activity of the renin- angiotensin - aldosterone system

Increased activity of the sympathetic-adrenal system

HDL

Chylomicrons

LDL

VLDL

4

3

1

2

chills

pale skin

increased blood pressure

intensive sweating

action of lymphotoxin mediators, transfer factors, macrophage activation factors

formation of IgE antibodies

formation of sensitized T-lymphocytes

implementation of antibody-dependent cytotoxicity

lactic acidosis

ketoacidosis

hyperkalemia

hypoglycemia

insulin resistance

destruction of β-cells of the islets of Langerhans by viruses

immune damage to β-cells of the islets of Langerhans

congenital abnormalities of insulin synthesis

activation of the complement system

formation of IgG, IgM antibodies

cell accumulation at the zone of an allergic reaction

effects of antibody- and complement-dependent cytotoxicity

Alteration → emigration of leukocytes → microcirculation disorder → proliferation

Alteration → formation of mediators → emigration of leukocytes and phagocytosis → reaction of the microvasculature → proliferation and regeneration

Alteration → formation of mediators and reaction of the microvasculature → exudation, emigration of leukocytes and phagocytosis → proliferation and regeneration

Alteration → microcirculation disorder → proliferation