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The distribution volume (V) of oxycodone is reported as 2.6 L/kg in drug database. Based on this data, what is the correct statement regarding oxycodone's distribution in the body?

Oxycodone preferentially distributes into the central nervous system, which serves as its primary site of action.

Oxycodone efficiently crosses biological barriers and distributes into both extracellular and intracellular fluids.

100%

Oxycodone's distribution volume suggests it remains primarily confined to the bloodstream.

Oxycodone undergoes significant and dangerous interactions with other drugs due to displacement from plasma albumin binding sites.

Only about 2% of oxycodone in the body is found in the systemic circulation, while approximately 98% resides outside the blood/plasma.

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Introduction to Pharmacology 25-26

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