Fentanyl TORREX is a short-acting opioid analgesic. In adult patients a dose of 1 μg i.v. fentanyl (base!) per kg bodyweight is required to induce analgesia. In the ICU you have a patient (an adult man weighing 85 kg) who needs to manage an acute pain attack. Fentanyl citrate (salt!) solution with concentration of 50 μg/mL is available. How much (how many mL) of fentanyl citrate have to be given to the patient?

Fentanyl (base) MW = 336.47 g/mol , Fentanyl (citrate) MW = 528.59 g/mol

Exercise: Reversible reaction of acetic acid with ethanol gives ethyl acetate and water. CH₃COOH (l) + CH₃CH₂OH (l) ↔ CH₃COOCH₂CH₃ (l) + H₂O (l). The reaction is exothermic. Where will the equilibrium of the reaction be shifted if we remove ethyl acetate from the reaction mixture by distillation?

Exercise: Reversible reaction of acetic acid with ethanol gives ethyl acetate and water. CH₃COOH (l) + CH₃CH₂OH (l) ↔ CH₃COOCH₂CH₃ (l) + H₂O (l). The reaction is exothermic. Where will the equilibrium of the reaction be shifted if we add water to the reaction mixture?

Exercise: Reversible reaction of acetic acid with ethanol gives ethyl acetate and water. CH₃COOH (l) + CH₃CH₂OH (l) ↔ CH₃COOCH₂CH₃ (l) + H₂O (l). The reaction is exothermic. Will the equilibrium of the reaction change if we increase the pressure?

Exercise: Let’s have the reaction PCl₅ ↔ PCl₃ + Cl₂. When the chemical equilibrium is reached, the rate of decomposition of phosphorus trichloride is the same as the rate of fusion of phosphorus trichloride with chlorine.