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After repeated severe pneumonia, often

accompanied by otitis media, the young paediatrician can no longer think of

many options for further examinations of the young 5-year-old patient. After a

thorough immunoassay, which reveals no deficiency in cellular or antibody

immunity, the tissue sample is sent for further electron microscopic

examination. This examination demonstrates the rare Kartagener syndrome, which

leads to dysfunctional cilia. The cilia are present, but due to the lack of a

molecular motor, they are immobile and cannot perform their cleansing role,

which leads, among other things, to frequent infections with a more severe

course. What is the name of the molecular motor present between the

microtubules in the cilia?

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A 58-year-old man with colorectal cancer comes to the

physician for a follow-up examination 6 weeks after

undergoing resection for the treatment of colorectal cancer. Physical

examination shows a clean, nontender scar on the lower abdomen. The physician

recommends an adjuvant treatment with cytostatics. Which of the following

types of cells are most affected by this therapy?

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The teacher wants to

demonstrate a typical serous gland to the students in practical exercises

focused on the glandular epithelium. However, he does not have much time to

think about it, because he has more tasks to complete. Which slide should he

choose to show the students typical serous acini?

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During a routine preventive examination, a

65-year-old patient is found to have an asymmetrically enlarged liver. The

patient himself admits that he drinks alcohol regularly and is therefore

referred for an ultrasound examination of the liver. The examination reveals a

prominent mass in the right lobe of the liver and a biopsy shows hepatocellular

carcinoma. After further investigations, the patient undergoes surgery during

which the tumour is removed. To confirm that the entire tumour has been

removed, including a sufficient margin of surrounding healthy liver tissue, the

resection is sent to pathology. What epithelium makes up the rim of healthy

liver tissue?

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A

26-year-old woman who is known to be

6 weeks pregnant presents with severe abdominal pain. An ultrasound is performed and demonstrates a corpus luteum cyst. The

following figure is obtained from the biopsy of the cyst. What is the function of the organelle indicated by the

arrow?

image

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A 4-year-old boy has recently returned from a holiday abroad and has now arrived now at the Clinic of Infectious Diseases with his parents due to severe

dehydration caused by diarrhoea. The causative bacterium is

Salmonella

,

which disrupts the structure of one type of intercellular junctions – tight

junction = zonula occludens. This physiologically prevents the passage of fluid

between cells – the so-called paracellular route. Disruption of these tight

junctions results in fluid loss into the lumen of the gastrointestinal tract.

Where can we find these tight junctions on cells?

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An investigator is studying the function of the endoplasmic reticulum in

genetically modified lymphocytes. One specific gene is removed. Its function is

to facilitate the binding of ribosomes to the endoplasmic reticulum. As a

result of this genetic modification, the binding of ribosomes to the ER was

disrupted. Which of the following processes describes the normal function of

this organelle?

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A 54-year-old man has

had issues with increased urinary frequency. More recently, he reports that he

has blood in his urine. Imaging shows a mass growing into the lumen of the

bladder, which is biopsied. Normal tissue adjacent to the mass will be of which

type of epithelium?

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The student is asked about the difference

between the basement membrane and the basal lamina during the histology exam.

Until now, he thought that the two terms were identical. Could you advise him

what the difference is between these two structures?

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Which of the following would be a presenting symptom in an

infant born with dysfunction of the structures in the

photomicrograph?

image

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