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Integrated Pharmacotherapy I

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A 60-year-old patient with high cholesterol is prescribed simvastatin to help lower LDL levels. The doctor explains that for some statins, the timing of the dose is important to achieve the best results. What is the best time of day for this patient to take simvastatin for maximum effectiveness?

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A 49-year-old woman with hypertension and obesity undergoes lipid screening. Her LDL cholesterol is 135 mg/dL, and her 10-year ASCVD risk score is 15%. She has no history of ASCVD or diabetes. Which statin therapy is most appropriate for this patient?

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Which structural feature in enalaprilat improves

its binding affinity to ACE’s zinc-binding site compared with captopril?

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A 58-year-old male patient taking propranolol for hypertension reports fatigue, difficulty sleeping, and decreased libido during a follow-up visit. Which of the following is a known adverse effect of propranolol?

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A 28-year-old woman at 30 weeks of pregnancy is newly diagnosed with hypertension. She has no proteinuria or other symptoms. Which of the following is the safest treatment option?

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A 32-year-old pregnant woman with hypertension is started on labetalol. She asks why not ACE inhibitors. What is the best explanation?
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A 45-year-old female with no significant medical history has an LDL cholesterol level of 190 mg/dL. What is the recommended treatment according to AHA guidelines?
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A 55-year-old woman with a family history of hypertension has office BP of 118/76 mmHg. However, she checks her BP at home, and her 7-day average is 138/84 mmHg. She reports occasional morning headaches. What is the most likely diagnosis?
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A 60-year-old patient with a history of myocardial infarction is on statin therapy. What is the AHA recommended LDL cholesterol goal for this patient?
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A 56-year-old woman with hypertension (average BP 146/90 mmHg)and prior stroke requires antihypertensive therapy. Which of the following combination is best?
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