What modification of the HTT gene would be needed to model Huntington’s disease in neuronal stem cells derived from an unaffected human?

Question

What modification of the  HTT  gene would be needed to model Huntington’s disease in neuronal stem cells derived from an unaffected human?

Answer

Addition of an additional 5’ exon

Answer

Addition of many CAG sequences

Answer

A reduction in trinucleotide repeats

Answer

Introduction of a STOP codon

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