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Codeine is a prodrug that requires metabolic conversion by the liver enzyme CYP...
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Codeine is a prodrug that requires metabolic conversion by the liver enzyme CYP2D6 to form morphine, which is responsible for most of its analgesic effect. Some drugs and genetic variants reduce or inhibit CYP2D6 activity.
If CYP2D6 activity is inhibited in a patient taking codeine, what outcome is MOST LIKELY with respect to pain relief?
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