A couple seeks reproductive counselling after genetic
testing reveals that the prospective mother carries a mutation in her
mitochondrial genome associated with a fatal childhood disorder. They wish to
reduce the risk of passing this condition to their child while retaining a
genetic link to both parents.

Which outcome best describes the intended role of
mitochondrial replacement therapy in this situation?

Question

A couple seeks reproductive counselling after genetic
testing reveals that the prospective mother carries a mutation in her
mitochondrial genome associated with a fatal childhood disorder. They wish to
reduce the risk of passing this condition to their child while retaining a
genetic link to both parents.

Which outcome best describes the intended role of
mitochondrial replacement therapy in this situation?

Accepted Answer

Prevention
of maternal transmission of disease-causing mitochondrial DNA to the offspring

Answer

Correction
of pathogenic variants within the child’s nuclear genome

Answer

Substitution
of dysfunctional mitochondria contributed by both parents with donor-derived
mitochondria

Answer

Restoration
of normal mitochondrial function in the mother before pregnancy

Crowdly

A couple seeks reproductive counselling after genetic testing reveals that the ...

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