Reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as nitric oxide

Complement components C5 and C9, which assemble directly on the phagolysosomal membrane to induce osmotic lysis of the internalized pathogen

Major basic protein (MBP) and eosinophil cationic protein (ECP), which form pores in the microbial cell wall via a calcium-dependent mechanism

Histamine and heparin, which increase the permeability of the phagosome to allow the influx of serum antibodies for intra-phagosomal neutralization

All of these