The

master clock causes irreversible mutation of peripheral metabolic enzymes

within 48 hours.

Gastrointestinal

transit time slows to zero, causing hyper-absorption of dietary lipids.

An

internal desynchrony occurs due to a phase mismatch between central sleep/wake

cycles, peripheral fasting/feeding cycles, and tissue metabolic cycles.

Central

circadian clocks in the hypothalamus completely halt peripheral insulin

receptor synthesis.