Haloperidol, chlorpromazine, and clozapine are antipsychotic medications that bind to the D2 subtype of dopamine receptors, with a binding affinity of haloperidol chlorpromazine clozapine. Which statement would have to be correct to conclude that the mechanism of antipsychotic effects for these drugs is via binding to D2 receptors?

Question

Haloperidol, chlorpromazine, and clozapine are antipsychotic medications that bind to the D2 subtype of dopamine receptors, with a binding affinity of haloperidol > chlorpromazine > clozapine. Which statement would have to be correct to conclude that the mechanism of antipsychotic effects for these drugs is via binding to D2 receptors?

Accepted Answer

A positive correlation should exist between the affinity of these drugs to bind to D2 receptors and their potency for antipsychotic actions.

Answer

Clozapine would have to be more potent than chlorpromazine for decreasing psychosis.

Answer

Haloperidol should have the lowest potency of the three antipsychotic drugs.

Answer

D2 receptor binding should also be related to the potency of these drugs in causing Parkinson's-like adverse effects.

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Haloperidol, chlorpromazine, and clozapine are antipsychotic medications that bi...

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