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Golongan metil xantin tidak direkomendasikan untuk terapi asma karena sebab berikut, kecuali…
Indeks terapi sempit
Banyak interaksi obat
Keamanan rendah karena banyak menyebabkan ADR
Efektivitas lebih rendah dibandingkan SABA + kortikosteroid
Harganya mahal
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