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What is the pathophysiological change in Parkinsons disease?

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What is the pathophysiological change in Parkinsons disease?

Deficit of acetylcholine and degeneration of the motor cortex in the frontal lobe

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Degeneration of motor fibers in the pyramidal tracts

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Degeneration of the basal nuclei with a deficit of dopamine

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Excess secretion of stimulatory neurotransmitters in the CNS

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