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When interpreting the results of a BLAST search, what does a lower E-value (clos...

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When interpreting the results of a BLAST search, what does a lower E-value (closer to zero) indicate about the sequence alignment?

The alignment represents a highly significant sequence similarity.

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The sequences are probably from different species.

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The alignment indicates a low level of sequence conservation.

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The alignment is likely due to random chance.

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