The overall number of proteins synthesized in eukaryotic cells compared to the number of genes or open reading frames (ORF) is

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Similar to the number of genes (taking into account that not all genes are transcribed in differentiated cells)

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Smaller than the number of genes, since some genes encode non-translated sequences (rRNA, snRNAs, microRNAs etc.)

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Significantly (several times) larger than the number of genes because of the alternative splicing

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Slightly larger than the number of genes because of the alternative splicing

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