As part of the phase 1 clinical trial program for a new drug, a single dose of the drug is given to healthy volunteers and blood samples are taken at regular intervals to establish plasma drug concentrations (Cp). The decrease in Cp over time is shown in the graph below.

Based on this, which of the following predictions could be made about this new drug? It is:

Question

As part of the phase 1 clinical trial program for a new drug, a single dose of the drug is given to healthy volunteers and blood samples are taken at regular intervals to establish plasma drug concentrations (Cp).  The decrease in Cp over time is shown in the graph below.  
  
 Based on this, which of the following predictions could be made about this new drug? It is:

Accepted Answer

having a saturable process in its elimination

Answer

removed from the body mostly in its unchanged form

Answer

a substrate for P-glycoproteins

Answer

being eliminated via first order elimination kinetics

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As part of the phase 1 clinical trial program for a new drug, a single dose of t...

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