What is the primary biochemical site of action and physiological outcome of Orlistat administration during nutrient digestion?

Question

Accepted Answer

Luminal competitive inhibition of gastric and
pancreatic lipases in the small intestine, resulting in fecal excretion of
30–35% of ingested fat.

Answer

Direct inhibition of chylomicron assembly within enterocytes, resulting in acute lipid accumulation within the intestinal brush border.

Answer

Antagonism of intestinal apical sodium-bile acid cotransporters, resulting in total malabsorption of fat-soluble vitamins and peptides.

Answer

Systemic
inhibition of hepatic fatty acid synthase, resulting in a 50% decrease in
circulating VLDL triglyceride incorporation.

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