An enzyme, E, displays negative cooperativity (allosteric behaviour) for its substrate, S, in the presence of a modulator, M.
Which curve below (A, or B) represents the dependence of the initial velocity of E on the concentration of S in the presence and absence of M.
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Question

An enzyme, E, displays negative cooperativity (allosteric behaviour) for its substrate, S, in the presence of a modulator, M.

Which curve below (A, or B) represents the dependence of the initial velocity of E on the concentration of S in the presence and absence of M.

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Answer

Curve B, because the substrate concentration required to give half-maximal velocity is  increased .

Answer

Curve A, because the substrate concentration required to give half-maximal velocity is  increased .

Answer

Curve A, because the substrate concentration required to give half-maximal velocity is  decreased .

Answer

Curve B, because the substrate concentration required to give half-maximal velocity is  decreased .

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