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Vancomycin is a glycopeptide antibiotic that blocks the formation of crosslinks between peptidoglycan tetramers in the bacterial cell wall. There are multiple mechanisms of resistance to vancomycin, but one of importance is the vanHAX operon, which works to alter the amino acid residues that are the site of crosslinking of peptidoglycan layers in Gram positive bacteria.
Based on this information, the vanHAX mediated resistance to Vancomycin is an example of: