The motor neuron terminal has vesicles each with a large amount of neurotransmitter.

The structure of the NMJ maximises the opportunity for ACh to remain in the cleft.

The folded surface of the motor end plate provides a large surface area that allows for a high density of ACh receptors

Presynaptic facilitation increases the amount of transmitter released and the size of the postsynaptic response

ACh binds to its receptors for longer than at most other receptor-transmitter interactions