Mammalian Red Blood Cells generally do not burst in a solution of 80% physiological saline because

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Their cell membranes have a higher concentration of cholesterol than membranes for other mammalian cells

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Their biconcave shape allows them to swell and accommodate some volume increase

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Their cell membranes are very much more fluid than membranes for other mammalian cells

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The fact that they don’t have a nucleus allows them to swell and accommodate some volume increase

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Their cell membranes have a higher number of saturated bonds than membranes for other mammalian cells

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