In the reciprocal pathway connecting OSA
and obesity, through which combination of neurohormonal mechanisms does OSA
actively exacerbate weight gain and metabolic deterioration?

Question

Accepted Answer

Sleep
fragmentation and short sleep induce leptin resistance and elevated ghrelin
while altering dietary choices and energy expenditure dynamics.

Answer

Upper
airway collapse directly suppresses pituitary TSH secretion, lowering basal
body temperature by 3.0 deg C.

Answer

Nocturnal
hypoxia destroys pancreatic beta cells, preventing insulin release and trapping
fat in blood vessels.

Answer

Intermittent
hypercapnia triggers irreversible hepatic steatosis through cortisol
suppression.

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In the reciprocal pathway connecting OSA and obesity, through which combination ...

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