The
combination therapy Contrave (Naltrexone/Bupropion) utilises "Rational
Pharmacology" to achieve weight loss by:

Question

Accepted Answer

Stimulating POMC neurons to release -MSH while blocking the -endorphin-mediated "brake" on those same neurons.

Answer

Activating both the GLP-1 and GIP receptors to improve glycaemic control and satiety.

Answer

Increasing the incretin effect in the gut while reducing glucose absorption in the jejunum.

Answer

Activating
the "Hungry Brain" while simultaneously increasing "Slow
Burn" energy expenditure.

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