A 56-year-old man presenting with
pulmonary embolism is administered drug A and drug B, as part of his
anti-coagulation treatment. Both drugs are highly bound to albumin (95%)
and were administered at dosages that saturate albumin binding sites.
Therapeutic levels of “free” drug for both medications have attained
steady-state plasma concentrations.

If drug B is suddenly
discontinued, what is the most likely immediate outcome on drug A?

Question

A 56-year-old man presenting with
pulmonary embolism is administered drug A and drug B, as part of his
anti-coagulation treatment. Both drugs are highly bound to albumin (>95%)
and were administered at dosages that saturate albumin binding sites.
Therapeutic levels of “free” drug for both medications have attained
steady-state plasma concentrations.

If drug B is suddenly
discontinued, what is the most likely immediate outcome on drug A?

Answer

The
free plasma concentration of drug A will be higher than the desired
steady-state concentration.

Answer

The
free plasma concentration of drug A will remain the same.

Answer

The
duration of activity of drug A will be extended because of enterohepatic recirculation.

Answer

The
free plasma concentration of drug A will be lower than the desired steady-state
concentration.

Answer

The
duration of activity of drug A will be extended because of redistribution from
fat.

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A 56-year-old man presenting with pulmonary embolism is administered drug A and ...

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