Peptide transmitters have uptake and/or re-uptake mechanisms

Enzyme degradation of a transmitter can be in the post-synaptic membrane

Transmitter can re-uptake into the pre-synaptic terminal or uptake into adjoining glial cells

Some transmitters can adapt several termination methods at different sites for the same transmitter

Transmitters can diffuse from the synaptic cleft and the post-synaptic receptors