Carlos is 64 years

old and visits his GP as he is concerned about his mid-life weight gain. He

knows that he is overweight and therefore at high risk of developing type 2

diabetes. Carlos’ GP requests a series of blood test and an oral glucose

tolerance test to be performed

Part A.

Carlos’

glucose tolerance test results suggest that he have insulin resistance.

Describe how insulin resistance in skeletal muscle, adipose tissue and the

liver leads to hyperglycaemia and impaired lipid metabolism (4 marks).

Part B.

Her GP

prescribes her with a biguanide drug. Describe what this is and how it affects glucose

in both skeletal muscle and the gut (4 marks)

Part C.

Six months

later, Cynthia returns to her GP who prescribes her with the weight loss drug Contrave.

Describe how it regulates food intake and blood glucose levels (4 marks)