The distribution of lipids within a single leaflet is neither uniform nor random. The outer leaflet can form a microdomain that is slightly thicker and enriched with specific membrane proteins, known as lipid rafts, which contain integral membrane proteins. What are the key features of lipid rafts?

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Lipid rafts are abundant in all cell membranes and are crucial for cell-cell communication

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They contain clusters of glycosphingolipids with very short typical "tails"

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They are part of the membrane where proteins are not permitted to segregate into the membrane

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They are susceptible to detergents in contrast to other proteins integrated into the membrane

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They serve as a platform for signal transduction and float freely within the liquid-disordered bilayer

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The distribution of lipids within a single leaflet is neither uniform nor random...

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