In mouse models of cancer cachexia, how did the selective genetic knockout of the glucocorticoid receptor in skeletal muscle (mGRKO) affect the response to Lewis Lung Carcinoma (LLC)?

Question

Accepted Answer

It resulted in significantly less muscle mass loss (gastrocnemius) and normalised the expression of pro-atrophy genes.

Answer

It completely prevented tumour development, leading to 100% tumour regression.

Answer

It accelerated the loss of skeletal muscle mass but preserved adipose tissue.

Answer

It increased local muscle glucocorticoid levels, leading to hyperactive protein synthesis.

Crowdly

In mouse models of cancer cachexia, how did the selective genetic knockout of th...

Want instant access to all verified answers on learning.monash.edu?