If an adult mouse is treated with a neutralizing antibody (such as JA16) that specifically blocks myostatin signalling, what is the expected physiological outcome on skeletal muscle mass?

Question

Accepted Answer

An increase of approximately 30% in muscle mass.

Answer

A massive synergistic increase of approximately 150% in muscle mass, which routinely occurs when blocking myostatin alone.

Answer

A decrease of approximately 30% in muscle mass due to accelerated protein degradation.

Answer

No change in muscle mass, as myostatin only regulates muscle development during embryonic stages.

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If an adult mouse is treated with a neutralizing antibody (such as JA16) that sp...

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