A microbiology laboratory isolates a bacterial pathogen that

is resistant to a ribosome‑targeting antimicrobial agent.

Further analysis shows the resistance is due to a bacterial enzyme that

inactivates the drug through covalent modification, which adds a phosphate,

preventing it from interacting with the ribosomal subunit. The affected drug is

water‑soluble

and depends on active transport systems to cross the bacterial cell envelope.

Which category of antibiotics most commonly exhibits this

type of resistance mechanism?