The PICO structure recommends that the question describes the population of interest, the intervention, the comparison and the outcomes of interest

The PICO structure should not be adapted to suit different types of questions (e.g. those that do not address treatment effectiveness)

PICO provides a structure for thinking about developing a focussed question about the effects of an intervention

The PICO structure is appropriate for the development of focussed questions related to cost effectiveness or prognosis