In mice, over-expression of the FTO gene leads to obesity, which of below is a mechanism that may underpin this weight gain:

Question

Accepted Answer

Reduced energy expenditure via a reduction in physical activity and reduced ‘browning’ of white adipose tissue leads to increased adiposity

Answer

Over-expression
of the FTO gene in mice increases ‘browning’ of white adipose tissue depots,
which leads to increased adiposity

Answer

Increased
food intake without any observable changes in food preference, which leads to
weight gain

Answer

FTO over-expression increases intake of highly caloric foods without an associated change in energy expenditure, leading to increased fat mass

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