Destruction of the insulin-producing beta cells

Citrullination or deamination of the autoantigen myelin basic protein (MBP), specifically arginine residues within the protein, is a hallmark of demyelination and CNS disorder

Citrullination of the immunodominant collagen II peptide

Mast cells releasing high amounts of IFN-α

Proliferation and de-differentiation of keratinocytes