After treatment with antibodies
targeting PD-1, tumour-infiltrating lymphocytes show increased proliferation
and enhanced tumour-cell killing.

Which mechanism BEST explains this
therapeutic effect?

Question

After treatment with antibodies
targeting PD-1, tumour-infiltrating lymphocytes show increased proliferation
and enhanced tumour-cell killing.

Which mechanism BEST explains this
therapeutic effect?

Accepted Answer

Disruption
of an immune checkpoint interaction that normally suppresses cytotoxic T-cell
responses against tumour cells

Answer

Direct induction of
DNA damage within tumour cells

Answer

Blocking
communication between tumour cells and stromal fibroblasts

Answer

Inhibition of
growth-factor signalling between tumour cells

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