Genome-wide association studies in patients with systemic
lupus erythematosus identify variants in genes regulating interferon responses,
antigen presentation, and lymphocyte activation thresholds. Many of these
variants influence immune signalling rather than directly damaging tissues.

Which interpretation BEST explains how these
findings inform our understanding of SLE pathogenesis?

Question

Genome-wide association studies in patients with systemic
lupus erythematosus identify variants in genes regulating interferon responses,
antigen presentation, and lymphocyte activation thresholds. Many of these
variants influence immune signalling rather than directly damaging tissues.

Which interpretation BEST explains how these
findings inform our understanding of SLE pathogenesis?

Answer

Cumulative
genetic variation alters immune regulation, increasing susceptibility to
pathological activation

Answer

Removal
of B cells eliminates the inherited genetic cause of disease

Answer

Lupus
is caused by organ-specific antibodies targeting liver cells

Answer

Autoimmunity
is driven solely by destruction of red blood cells

Crowdly

Genome-wide association studies in patients with systemic lupus erythematosus i...

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