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During lead optimisation, all lead compounds were evaluated using the forced sw...
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During lead optimisation, all lead compounds were evaluated using the forced swim test in mice.
Table 2: Assessment of in vivo efficacy of lead compounds in rodents
In the forced swim test, decreased immobility is considered to be associated with antidepressant activity
Lead Compound | Forced swim test in mice Time mice are immobile (s) |
Placebo | 154 ± 10 |
EL-01 (200µmol/kg) | 131 ± 8 |
EL-02 (200µmol/kg) | 95 ± 13 |
EL-03 (200µmol/kg) | 161 ± 9 |
EL-04 (200µmol/kg) | 120 ± 6 |
Values given as mean ± SEM
Based upon the data shown in Table 2, which of the compounds is MOST LIKELY to be effective in the treatment of patients with severe depression?