According to the Brenner Hypothesis, reduced nephron
endowment increases functional demand on individual nephrons, leading to an
increased risk of chronic kidney disease. A researcher studies a cohort of
adults by directly measuring nephron number, single‑nephron
glomerular filtration rate (SNGFR), glomerular size, podocyte density, and
blood pressure.

Which pattern of findings would most strongly support the
Brenner Hypothesis?

Question

According to the Brenner Hypothesis, reduced nephron
endowment increases functional demand on individual nephrons, leading to an
increased risk of chronic kidney disease. A researcher studies a cohort of
adults by directly measuring nephron number, single‑nephron
glomerular filtration rate (SNGFR), glomerular size, podocyte density, and
blood pressure.

Which pattern of findings would most strongly support the
Brenner Hypothesis?

Accepted Answer

Individuals
with fewer nephrons exhibit increased SNGFR per nephron, glomerular hypertrophy
with reduced podocyte density, higher rates of glomerulosclerosis, and elevated
blood pressure

Answer

Podocyte
density is reduced in low-nephron individuals without changes in filtration or
blood pressure

Answer

Increased
SNGFR occurs without changes in glomerular size, podocyte density, or blood
pressure

Answer

Individuals
with fewer nephrons show proportionally reduced filtration without structural
changes and normal blood pressure

Crowdly

According to the Brenner Hypothesis, reduced nephron endowment increases functi...

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