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To obtain exotoxins of some microorganisms, these microorganisms are inoculated ...

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To obtain exotoxins of some microorganisms, these microorganisms are inoculated into liquid nutrient medium, where microbial cultivation occurs and toxins are produced. At a certain stage it is necessary to remove the microbial cells from the medium, that is, to separate the toxins from microbes. What method should be applied in this case?
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