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A 35-year-old male is brought in by ambulance with an overdose of paracetamol. He was found by neighbours alone in his unit. He had written a suicide note that says he took 50 tablets of 500mg, dated 3 days ago.
On arrival, he is jaundiced. HR 105, BP 105/90, RR 24, Temp 36.1. He is unable to follow commands and is disorientated to time place and person.
His pathology findings are:
Which
of the following is the most immediate management in the ED?