A mutation causes a signalling protein
to activate downstream proliferation pathways continuously, even without ligand
stimulation. In this case only one allele of the gene carries the mutation.

Which explanation BEST accounts for
this effect?

Question

A mutation causes a signalling protein
to activate downstream proliferation pathways continuously, even without ligand
stimulation. In this case only one allele of the gene carries the mutation.

Which explanation BEST accounts for
this effect?

Accepted Answer

A
dominant gain-of-function mutation that activates a proto-oncogene and promotes
oncogenic signalling

Answer

A recessive loss-of-function
mutation that disables both alleles of a proto-oncogene

Answer

Gene amplification
leading to increased transcription of an inactive signalling protein

Answer

Deletion of a tumour
suppressor gene that normally inhibits cell proliferation

Crowdly

A mutation causes a signalling protein to activate downstream proliferation pat...

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