When neutrophils leave the blood circulation, they first need to bind to blood vessel endothelial cells in a specific manner and at the right location. In this process, the surface integrin on the leukocyte changes from a low affinity state to a high affinity state. What does this mean?

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The strength of binding of the integrin is increased

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The cells accumulate (swarm) to the vessel wall increasing integrin concentration at the site

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The number of integrin molecules that cluster on the cell surface is increased

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The distance that the integrin extends from the cell surface is increased

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When neutrophils leave the blood circulation, they first need to bind to blood v...

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