Two bacterial species isolated from the same patient both
contain the molecular target of a newly developed antibiotic, and sequencing
confirms the target protein has an identical amino acid sequence in both
organisms. Despite this, one species is rapidly killed by the drug, while the
other shows no detectable growth inhibition.

Which explanation most convincingly accounts for
this difference in susceptibility?

Question

Two bacterial species isolated from the same patient both
contain the molecular target of a newly developed antibiotic, and sequencing
confirms the target protein has an identical amino acid sequence in both
organisms. Despite this, one species is rapidly killed by the drug, while the
other shows no detectable growth inhibition.

Which explanation most convincingly accounts for
this difference in susceptibility?

Accepted Answer

The
resistant species has limited capacity to import the antibiotic

Answer

The
target protein is overexpressed in the resistant species

Answer

Differences
in the host immune response affect drug efficacy

Answer

The
susceptible species replicates more rapidly

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