Inherited gene mutations cause primary immunodeficiency diseases. Primary immunodeficiency

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Is not associated with defects in the thymic function that blocks T cell development

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Are not inherited defects in the cytolytic pathway of lymphocytes

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Is acquired from a virus

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Can be defects in antigen receptor gene rearrangement and results in so-called severe combined immunodeficiency (SCID)

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Is not caused by inherited gene mutations

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