Cholecystokinin
(CCK) is distinct from other satiety peptides like PYY and GLP-1 in its site
and mechanism of action because:

Question

Accepted Answer

CCK
reduces food intake exclusively through actions on vagal afferent fibres
signalling to the NTS, unlike GLP-1 which can act directly on neurons in the
hypothalamus.

Answer

CCK
levels peak 6 hours after a meal, whereas PYY and GLP-1 levels peak within 15
minutes.

Answer

CCK
crosses the blood-brain barrier directly to act on the PVN, whereas PYY acts
only on the Area Postrema.

Answer

CCK
is secreted from L-cells in the rectum, while PYY is secreted from I-cells in
the duodenum.

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Cholecystokinin (CCK) is distinct from other satiety peptides like PYY and GLP-1...

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