How do semaglutides act on hypothalamic neuronal populations to regulate appetite?

Question

Accepted Answer

Direct activation of POMC neurons and indirect
inhibition of NPY/AgRP neurons via GABAergic interneurons.

Answer

Direct stimulation of both POMC
and NPY/AgRP neurons simultaneously.

Answer

Selective blockade of MC4R
receptors in the paraventricular nucleus.

Answer

Direct inhibition of POMC neurons
and direct activation of NPY/AgRP neurons.

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