Following antigen encounter, antigen-specific B cells and
CD4⁺ T cells must interact to initiate a T cell–dependent antibody response.
This requires coordinated changes in cell migration within secondary lymphoid
organs.

Which observation would provide the strongest
evidence that this migratory coordination between B cells and T cells is
functioning correctly?

Question

Following antigen encounter, antigen-specific B cells and
CD4⁺ T cells must interact to initiate a T cell–dependent antibody response.
This requires coordinated changes in cell migration within secondary lymphoid
organs.

Which observation would provide the strongest
evidence that this migratory coordination between B cells and T cells is
functioning correctly?

Answer

B
cells and T cells remain confined to their original zones until germinal
centres form

Answer

Antigen-specific
B cells and T cells accumulate at the boundary between B cell follicles and T
cell zones

Answer

Antigen-bearing
dendritic cells simultaneously engage B cells and T cells for prolonged periods

Answer

T
cells upregulate CXCR5 and migrate deep into B cell follicles immediately after
activation

Crowdly

Following antigen encounter, antigen-specific B cells and CD4⁺ T cells must int...

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