Following TLR signalling to trigger the inflammasome, the only outcome from this will be to drive the assembly of the NLRP3, adaptor molecule and Caspase-1 complex.

The supply of pro-IL-1b within the cell is entirely from stores found in the cytoplasm that can be utilised instantly.

Structurally, Pro-IL-1b and IL-1b are identical

The leaking of K+ ions from the cells is a signal of cell stress.

The need to recognise and deal with dead and damaged host tissues is also an important trigger for the inflammasome.